BOSTON—Findings published in PLoS ONE explain the myriad effects of naringenin, a flavonoid found in grapefruit as a non-toxic, naturally occurring LXR-alpha inhibitor (2010;5(8): e12399. DOI:10.1371/journal.pone.0012399). Naringenin has been shown to normalize lipids in diabetes and hypercholesterolemia. Disruption of lipid and carbohydrate homeostasis is an important factor in the development of prevalent metabolic diseases such as diabetes, obesity and atherosclerosis. As a result, small molecules that could reduce insulin dependence and regulate dyslipidemia could have a dramatic effect on public health.

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Q: Is it true that red wine is good for one’s health?

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